February 1, 1978AJP Heart and Circulatory Physiology

Action of prostaglandins, endoperoxides, and thromboxanes on the lamb ductus arteriosus

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Population

Circular strips of ductus arteriosus from mature fetal lambs

Design

Preclinical

Authors

FCFlavio CoceaniScuola Superiore Sant'Anna IBIsis BishaiHospital for Sick Children EWE. WhiteThe Kids Research Institute Australia

Discussion

Member takes

Implication

Supports PGE2-mediated ductal relaxation in fetal hypoxia models; leaves open human translation and therapeutic targeting.

Structured PICO

Population

Circular strips of ductus arteriosus from mature fetal lambs

Intervention

Prostaglandin (PG) E2, PG endoperoxides PGG2 and PGH2, enzymatically generated PGI2, and thromboxane A2 (TXA2) in vitro

Outcome

Relaxation of the ductus arteriosus at low PO2 (7-11 torr) and high PO2 (410-660 torr)surrogate

PGE2 is the most effective prostaglandin for relaxing the fetal ductus arteriosus at low oxygen tensions, supporting its role in maintaining ductal patency during fetal life.

Cite This Study

Coceani et al. (1978) studied this question.

synapsesocial.com/papers/6a967e802d8f86faeeb2e9b1 https://doi.org/10.1152/ajpheart.1978.234.2.h117

View Full Paper

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Action of prostaglandins, endoperoxides, and thromboxanes on the lamb ductus arteriosus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Action of prostaglandins, endoperoxides, and thromboxanes on the lamb ductus arteriosus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider