June 1, 1986Canadian Journal of Physiology and Pharmacology

Involvement of intramural prostaglandin E2 in prenatal patency of the lamb ductus arteriosus

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Population

Isolated ductus arteriosus preparations from immature and near-term fetal lambs

Design

Preclinical

Authors

FCFlavio CoceaniScuola Superiore Sant'Anna DHD HuhtanenWestern University NHN. HamiltonTufts University

Discussion

Member takes

Implication

Supports local PGE2 in fetal lamb ductus; leaves open human perinatal translation.

Structured PICO

Population

Isolated ductus arteriosus preparations from immature (103 or 104 days gestation) and near-term (term, 147 days) fetal lambs

Intervention

Exposure to varying PO2 levels, excess potassium, carbon monoxide, reduced glutathione, and indomethacin, as well as tissue stripping (adventitia/intima removal)

Outcome

Release rate of prostaglandin E2 (PGE2) and its relationship to intrinsic tone and PO2 levelssurrogate

The fetal lamb ductus arteriosus intrinsically synthesizes PGE2, which plays a key effector role in regulating tone and maintaining prenatal patency.

Cite This Study

Coceani et al. (1986) studied this question.

synapsesocial.com/papers/6a8938e00f137e402b33345e https://doi.org/10.1139/y86-124

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Involvement of intramural prostaglandin E2 in prenatal patency of the lamb ductus arteriosus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Involvement of intramural prostaglandin E2 in prenatal patency of the lamb ductus arteriosus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider