Key result
In lamb ductus arteriosus studied in vitro, ibuprofen produced a dose-dependent contraction at all gestational ages and enhanced potassium- and oxygen-induced contractions in immature ductus.
Why the study?
Does ibuprofen induce contraction in the preterm lamb ductus arteriosus in vitro?
Population
Circular strips of ductus arteriosus from lambs of gestational age between 90 and 144 days studied in vitro.
Design
Preclinical
Authors
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Supports mechanistic rationale for ibuprofen in PDA; leaves open confirmation in human preterm neonates.
Does ibuprofen induce contraction in the preterm lamb ductus arteriosus in vitro?
Ibuprofen induces dose-dependent contraction of the preterm lamb ductus arteriosus in vitro, supporting its physiological mechanism for managing patent ductus arteriosus in premature infants.
Coceani et al. (1979) studied Patent ductus arteriosus. Oxygen and ibuprofen was evaluated on Contraction of the ductus arteriosus. In lamb ductus arteriosus studied in vitro, ibuprofen produced a dose-dependent contraction at all gestational ages and enhanced potassium- and oxygen-induced contractions in immature ductus.
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