Why the study?
Do prostaglandins E1 and E2 relax lamb ductus arteriosus tissue under anaerobic and aerobic conditions?
Do prostaglandins E1 and E2 relax lamb ductus arteriosus tissue under anaerobic and aerobic conditions?
Prostaglandins E1 and E2 effectively relax the anoxic lamb ductus arteriosus, suggesting a role in regulating vessel tone during fetal life.
Prostaglandins E1 and E2 may regulate fetal ductus tone under hypoxia; animal data leave open human neonatal relevance.
Effects of various prostaglandin types on strips of lamb ductus arteriosus were investigated under anaerobic and aerobic conditions. Prostaglandins E 1 and E 2 relaxed markedly the anoxic ductus over a dose range from 10 −9 to 10 −5 M whereas they had little or no effect on the tissue after exposure to oxygen. This is in contrast to papaverine which relaxed the ductus to a similar degree before and after exposure to oxygen. An additional finding was that prostaglandins E 1 and E 2 are less active on the anoxic tissue depolarized by excess potassium. The greater effectiveness of prostaglandins on the anoxic ductus suggests a role for these compounds in the regulation of the vessel tone during fetal life.
No takes yet. Share an insight, caveat, or question.
Coceani et al. (1973) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: