Why the study?
Does prostaglandin E2 inhibit the response of isolated fetal rabbit ductus arteriosus to norepinephrine under varying oxygen tensions?
Does prostaglandin E2 inhibit the response of isolated fetal rabbit ductus arteriosus to norepinephrine under varying oxygen tensions?
Prostaglandin E2 synergistically inhibits the contractile response of the fetal ductus arteriosus to vasoconstrictors under fetal oxygen tensions, an effect that is abolished by the increased oxygen tensions occurring at birth.
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Supports PGE2-mediated ductal relaxation in fetal oxygen; leaves open translation to human neonatal ductal closure.
Smith et al. (1991) studied this question.
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