Why the study?
Does indomethacin or oxygen tension affect the sensitivity of isolated neonatal rabbit ductus arteriosus and aorta to noradrenaline?
Does indomethacin or oxygen tension affect the sensitivity of isolated neonatal rabbit ductus arteriosus and aorta to noradrenaline?
Intramurally synthesised cyclo-oxygenase products, most likely prostaglandins, attenuate the sensitivity of the neonatal ductus arteriosus to noradrenaline.
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Does not inform neonatal ductal management; leaves open prostaglandin attenuation of noradrenaline sensitivity for in vivo study.
Smith et al. (1988) studied this question.
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