Why the study?
Does oxygenation induce contraction and increase intracellular calcium in the isolated fetal rabbit ductus arteriosus?
Does oxygenation induce contraction and increase intracellular calcium in the isolated fetal rabbit ductus arteriosus?
Oxygen induces contraction of the fetal ductus arteriosus by increasing intracellular calcium influx, likely via closure of ATP-sensitive potassium channels and subsequent membrane depolarization.
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No immediate change to neonatal practice; leaves open translation of calcium-dependent ductal mechanisms to human newborns.
Nakanishi et al. (1993) studied this question.
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