Key result
Application of oxygen to isolated neonatal guinea pig ductus arteriosus resulted in sustained membrane depolarization from -54.8 mV to -32.9 mV and tonic contraction.
Why the study?
Does oxygen application induce contraction and membrane depolarization in the isolated neonatal guinea pig ductus arteriosus?
Population
Ductus arteriosus isolated from neonatal guinea pigs
Comparison
Application of oxygen vs Low Po2 (less than 40 mm Hg)
Design
Preclinical
Authors
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Provides mechanistic insight into oxygen-mediated ductus arteriosus closure; leaves open applicability to human neonates and clinical oxygen strategies.
Does oxygen application induce contraction and membrane depolarization in the isolated neonatal guinea pig ductus arteriosus?
Absolute Event Rate: -32.9% vs -54.8%
Oxygen induces contraction in the neonatal guinea pig ductus arteriosus via a conductance change in the sarcolemma resulting in depolarization, alongside a membrane potential-independent mechanism.
Roulet et al. (1981) studied this question. Oxygen (high Po2) vs. Low Po2 (< 40 mm Hg) was evaluated on Membrane potential. Application of oxygen to isolated neonatal guinea pig ductus arteriosus resulted in sustained membrane depolarization from -54.8 mV to -32.9 mV and tonic contraction.
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