Population
Isolated ductus arteriosus preparations from mature fetal lambs and guinea pigs
Comparison
Carbon monoxide (CO) and metyrapone vs Control conditions and different O2 partial…
Design
Preclinical
Authors
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Species differences limit translation of lamb ductus findings; leaves open cytochrome P450 role in human fetal ductal tone.
A cytochrome P450-catalyzed enzymatic process is implicated in the maintenance of muscle tone and the contractile response to oxygen in the fetal lamb ductus arteriosus.
Coceani et al. (1984) studied this question.
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