Key result
Oxygen had no significant effect on skinned ductal muscle preparations, indicating that oxygen exerts its effect on the plasma membrane via a membrane-bound cytochrome P-450 signal transducer.
Population
Saponin-skinned strips of ductal muscle from mature fetal lambs
Comparison
Oxygen and carbon monoxide vs Absence of oxygen/CO; varying free Ca2+…
Design
Preclinical
Authors
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Supports membrane cytochrome P-450 as oxygen transducer in ductus arteriosus; extends mechanistic insights but remains hypothesis-generating for clinical translation.
The study suggests that a membrane-bound cytochrome P-450 mechanism functions as the signal transducer for oxygen-induced constriction in the ductus arteriosus.
Coceani et al. (1989) studied Ductus arteriosus oxygen constriction. Oxygen and Carbon monoxide was evaluated on Contraction or relaxation of skinned preparations. Oxygen had no significant effect on skinned ductal muscle preparations, indicating that oxygen exerts its effect on the plasma membrane via a membrane-bound cytochrome P-450 signal transducer.