Key result
Elective bilateral lung irradiation provided the same survival as adjuvant chemotherapy in patients with limb osteosarcoma, with an overall 4-year disease-free survival of 24% and total survival of 43%.
Why the study?
Does adjuvant chemotherapy, prophylactic lung irradiation, or their combination improve survival in patients with osteosarcoma of the limbs?
RCT (n=205)
randomized
Yes
Does adjuvant chemotherapy, prophylactic lung irradiation, or their combination improve survival in patients with osteosarcoma of the limbs?
Elective lung irradiation provided the same survival as adjuvant chemotherapy for osteosarcoma of the limbs in this historical cohort.
No takes yet. Share an insight, caveat, or question.
Lung irradiation matches chemotherapy for survival; confirms equivalence but leaves open need for superior regimens in limb osteosarcoma.
Burgers et al. (1988) conducted an RCT in osteosarcoma of the limbs (n=205). Adjuvant chemotherapy and/or prophylactic lung irradiation vs. Compared among 3 arms (9 months chemotherapy, 20 Gy lung irradiation, or 3 months chemotherapy plus lung irradiation) was evaluated on 4-year disease-free survival and total survival. Elective bilateral lung irradiation provided the same survival as adjuvant chemotherapy in patients with limb osteosarcoma, with an overall 4-year disease-free survival of 24% and total survival of 43%.
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