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April 1, 1970Journal of Bone and Joint Surgery

Osteogenic Sarcoma under the Age of Twenty-one

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Why the study?

What is the natural history and 5-year survival rate of central-type osteogenic sarcoma in the long bones of patients under 21 years of age?

Population

145 patients under the age of twenty-one years with central-type osteogenic sarcomas in the long bones.

Design

Cohort

Follow-up

5 years

Authors

RMRalph C. MarcoveMemorial Sloan Kettering Cancer CenterVMValerie MikéMemorial Sloan Kettering Cancer CenterJHJ HájekMassachusetts Eye and Ear Infirmary

Discussion

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Implication

Provides a historical control benchmark for central osteogenic sarcoma in adolescents; leaves open the impact of modern therapies.

Structured PICO

What is the natural history and 5-year survival rate of central-type osteogenic sarcoma in the long bones of patients under 21 years of age?

P
Population
145 patients under the age of twenty-one years with central-type osteogenic sarcomas in the long bones.
I
Intervention
Surgery (with analysis of preoperative radiation, time of surgery, etc.)
O
Outcome
Interval from surgery to onset of pulmonary metastasis, interval from onset of pulmonary metastasis to death, and 5-year survival ratehard clinical

The 5-year survival rate for osteogenic sarcoma in patients under 21 was 17.4%, providing a historical control series for evaluating future treatments.

Cite This Study

Marcove et al. (1970) studied this question.

synapsesocial.com/papers/6a70c1fef44fa9f079de73fehttps://doi.org/10.2106/00004623-197052030-00001
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Also Consider

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  1. 1Primary Osteosarcoma of Bone: A Clinicopathologic Investigation of 243 Cases, with Necropsy Studies in 541977 · 124 citations
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  4. 4The Treatment of Pulmonary Metastasis in Osteogenic Sarcoma1975 · 51 citations
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