Key result
Malignant fibrous histiocytoma cells expressed mesenchymal antigens but lacked monocyte-macrophage lineage markers, suggesting they are facultative histiocytes showing mesenchymal differentiation.
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Supports mesenchymal differentiation of MFH; hypothesis-generating and requires validation before diagnostic use.
Iwasaki et al. (1992) studied Malignant fibrous histiocytoma (n=17). Cell line analysis vs. Monocyte-derived macrophages was evaluated on Cellular origin and characteristics. Malignant fibrous histiocytoma cells expressed mesenchymal antigens but lacked monocyte-macrophage lineage markers, suggesting they are facultative histiocytes showing mesenchymal differentiation.
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