Key result
Hyperhomocysteinemia is a significant risk factor for postoperative vascular complications, driven by oxidative stress and endothelial dysfunction, which can be managed with targeted therapy.
Hyperhomocysteinemia is a risk factor for cardiovascular morbidity and postoperative vascular complications, with potential for successful correction.
Hyperhomocysteinemia may influence post-intervention cardiovascular outcomes; leaves open its role in risk stratification pending prospective validation.
Hyperhomocysteinemia is one of the unconventional risk factors of cardiovascular morbidity - it is causally associated in both directions with oxidative stress, endothelial dysfunction, mechanisms of cell signaling and apoptosis. Numerous clinical and experimental studies have explained the mechanisms and clinical expression of atherosclerotic and prothrombotic effects of homocysteine. The main pathological substrate, previous therapy, and surgical procedure-intervention itself are associated with the state of oxidative stress and endothelial dysfunction, which is one of important factors for elevated plasma homocysteine levels. Recent studies point to the possibility of a successful correction of hyperhomocysteinemia, especially secondary one.
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Vučinić et al. (2016) conducted a review in Hyperhomocysteinemia and postoperative vascular complications. Hyperhomocysteinemia was evaluated. Hyperhomocysteinemia is a significant risk factor for postoperative vascular complications, driven by oxidative stress and endothelial dysfunction, which can be managed with targeted therapy.
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