What question did this study set out to answer?

To determine whether SARS-CoV-2 variants of concern evade humoral and cellular immune responses in individuals who were previously infected or vaccinated.

May 25, 2021Science ImmunologyOpen Access

SARS-CoV-2 variants of concern partially escape humoral but not T cell responses in COVID-19 convalescent donors and vaccine recipients

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Authors

DGDaryl GeersErasmus MC MSMarc C. ShamierErasmus MC SBSusanne BogersErasmus MC

Discussion

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Implication

Immunological study demonstrates SARS-CoV-2 variants evade antibodies but not CD4+ T cells in vaccinated and convalescent donors, indicating durable cellular defense.

Key Points

To determine whether SARS-CoV-2 variants of concern evade humoral and cellular immune responses in individuals who were previously infected or vaccinated.
Assessed humoral and CD4+ T cell responses in COVID-19 convalescent donors and vaccine recipients.
Evaluated the cross-reactivity of spike-specific CD4+ T cells against mutations characteristic of SARS-CoV-2 variants of concern.
SARS-CoV-2 variants of concern partially escaped neutralizing antibody-mediated humoral responses.
Spike-specific CD4+ T cell responses induced by either natural infection or vaccination remained robust and indifferent to the mutations present in variants of concern.

Cite This Study

Geers et al. (2021) studied this question.

synapsesocial.com/papers/6a9e5eda9b2dbee2f9368a0f https://doi.org/10.1126/sciimmunol.abj1750

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Implication

Immunological study demonstrates SARS-CoV-2 variants evade antibodies but not CD4+ T cells in vaccinated and convalescent donors, indicating durable cellular defense.

SARS-CoV-2 variants of concern partially escape humoral but not T cell responses in COVID-19 convalescent donors and vaccine recipients

Discussion

Member takes

Implication

Key Points

Cite This Study

SARS-CoV-2 variants of concern partially escape humoral but not T cell responses in COVID-19 convalescent donors and vaccine recipients

Discussion

Member takes

Implication

Key Points

Cite This Study

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