Key result
Cigarette smoking significantly impaired the antihypertensive efficacy of propranolol in patients with mild hypertension, but did not affect the efficacy of bendrofluazide.
Why the study?
Does smoking affect the antihypertensive efficacy of propranolol and bendrofluazide in patients with mild hypertension?
Does smoking affect the antihypertensive efficacy of propranolol and bendrofluazide in patients with mild hypertension?
Answers are grounded in this paper and cite their sources.
Smoking significantly impairs the blood pressure-lowering effect of propranolol, but not bendrofluazide, which may explain reduced cardiovascular protection with beta-blockers in smokers.
The antihypertensive efficacy of propranolol in the treatment of mild hypertension was significantly impaired in cigarette smokers, whereas that of bendrofluazide was not affected by smoking habit. This diminished efficacy of propranolol in smokers may be one of several possible factors operating to reduce its primary preventive action against strokes, and possibly against coronary events.
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Gillian Greenberg (1987) studied this question. Cigarette smoking significantly impaired the antihypertensive efficacy of propranolol in patients with mild hypertension, but did not affect the efficacy of bendrofluazide.
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