Key result
Bendrofluazide added to propranolol enhances BP lowering in essential hypertension, maximizing supine systolic reductions.
Why the study?
Does bendrofluazide reduce blood pressure in patients with essential hypertension controlled on propranolol?
Does bendrofluazide reduce blood pressure in patients with essential hypertension controlled on propranolol?
Bendrofluazide provides an additional hypotensive effect when added to propranolol in patients with essential hypertension.
Answers are grounded in this paper and cite their sources.
Supports adding bendrofluazide to propranolol for enhanced BP control; extends RCT evidence for combination therapy in essential hypertension.
A double-blind trial was undertaken to assess the effect of bendro-fluazide in lowering the blood pressure in patients with essential hypertension controlled on propranolol. An increased hypotensive effect was found and the greatest fall occurred in the supine systolic blood pressure. Side-effects were mild and transient and did not interfere with treatment.
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Mitchell et al. (1972) studied this question. Bendrofluazide added to propranolol increased the hypotensive effect in patients with essential hypertension, producing the greatest fall in supine systolic blood pressure.
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