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December 1, 1987Journal of Hypertension

A Double-Blind Study of the Blood Pressure Lowering Effect of a Thiazide Diuretic in Hypertensive Patients Already on Nifedipine and a Beta-Blocker

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Why the study?

Does the addition of bendrofluazide reduce blood pressure in hypertensive patients already on atenolol and nifedipine?

Population

12 hypertensive patients already on treatment with atenolol and nifedipine

Comparison

Bendrofluazide 5 mg once daily added for 1 month vs Matching placebo added for 1 month

Design

RCT, randomized crossover, double-blind

Follow-up

1 month

Authors

FCFrancesco P. CappuccioNMNirmala D. MarkanduFTFelicity A. Tucker

Discussion

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Overview

No additive BP effect from bendrofluazide on atenolol-nifedipine; challenges routine triple-therapy assumptions in hypertension.

Structured PICO

Does the addition of bendrofluazide reduce blood pressure in hypertensive patients already on atenolol and nifedipine?

P
Population
12 hypertensive patients already on treatment with atenolol (100 mg once daily) and nifedipine (20 mg twice daily)
I
Intervention
Bendrofluazide 5 mg once daily added for 1 month
C
Comparator
Matching placebo added for 1 month
O
Outcome
Blood pressure 2 h after the last dose of nifedipinesurrogate

Adding a thiazide diuretic to a combination of a beta-blocker and a calcium channel blocker provides little additive blood pressure lowering effect but increases plasma urate.

Cite This Study

Cappuccio et al. (1987) studied this question.

synapsesocial.com/papers/6a8af237fe910689a2892bf2https://doi.org/10.1097/00004872-198712000-00017
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Effects of Bendroflumethiazide Added to Nifedipine in Patients With Hypertension1987 · 10 citations
  2. 2Controlled Trial of Nifedipine and Bendroflumethiazide in Hypertension1983 · 68 citations
  3. 3Treating Hypertension in Non‐insulin‐Dependent Diabetes: A Comparison of Atenolol, Nifedipine, and Captopril Combined with Bendrofluazide1987 · 29 citations
  4. 4A Diuretic Is More Effective Than a β-Blocker in Hypertensive Patients Not Controlled on Amlodipine and Lisinopril1996 · 13 citations
  5. 5Nifedipine tablet vs. hydralazine in patients with persisting hypertension who receive combined diuretic and beta-blocker therapy1986 · 11 citations