Why the study?
Does the addition of atenolol, nifedipine, or captopril to bendrofluazide improve blood pressure in hypertensive non-insulin-dependent diabetics?
Population
25 non-insulin-dependent diabetics who remained hypertensive after 4 weeks on bendrofluazide 2.5 mg daily
Comparison
Atenolol, slow-release nifedipine, or captopril… vs Bendrofluazide 2.5 mg daily alone, as well as…
Design
RCT, randomized crossover study, single-blind, observer-blind
Follow-up
8 weeks per treatment period
Authors
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Supports adding atenolol, nifedipine or captopril to bendrofluazide for BP control in diabetic hypertension; extends comparative data on add-on regimens.
Does the addition of atenolol, nifedipine, or captopril to bendrofluazide improve blood pressure in hypertensive non-insulin-dependent diabetics?
Adding atenolol, nifedipine, or captopril to bendrofluazide effectively lowers blood pressure in hypertensive patients with non-insulin-dependent diabetes without adversely affecting renal function or peripheral blood flow.
Corcoran et al. (1987) studied this question.
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