Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 1, 1983Journal of Cardiovascular Pharmacology

Controlled Trial of Nifedipine and Bendroflumethiazide in Hypertension

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does nifedipine, bendroflumethiazide, or their combination reduce blood pressure in patients with mild or moderate hypertension?

Population

30 patients with mild or moderate (World Health Organization classification I or II) hypertension

Comparison

Nifedipine 20 mg twice a day or… vs Active comparator and placebo

Design

RCT, double-blind

Follow-up

30 weeks (24 weeks monotherapy + 6 weeks combination)

Authors

LHLena HallinLALennart AndrénLHLennart Hansson

Discussion

Loading...

Member takes

Overview

Supports low-dose nifedipine-bendroflumethiazide combination for additive BP lowering in mild-moderate hypertension; extends monotherapy data with RCT confirmation of efficacy.

Key Points

  • To assess the individual and combined antihypertensive efficacy of nifedipine and bendroflumethiazide in patients with mild or moderate hypertension.
  • Double-blind study conducted in 30 patients with WHO stage I or II hypertension.
  • Patients received either nifedipine (20 mg twice daily) or bendroflumethiazide (2.5 mg with 0.57 g KCl twice daily) for 24 weeks, followed by 6 weeks of combined therapy using half the initial doses.
  • Monotherapy significantly reduced blood pressure: nifedipine decreased supine pressure by 16/10 mm Hg and standing by 11/5 mm Hg; bendroflumethiazide decreased recumbent pressure by 15/10 mm Hg and standing by 11/10 mm Hg.
  • Combined low-dose therapy produced additional reductions, totaling 23/12 mm Hg supine (p < 0.001) and 17/11 mm Hg standing (p < 0.001) versus placebo, with no significant correlation between blood pressure reduction and patient age.

Structured PICO

Does nifedipine, bendroflumethiazide, or their combination reduce blood pressure in patients with mild or moderate hypertension?

P
Population
30 patients with mild or moderate (World Health Organization classification I or II) hypertension
I
Intervention
Nifedipine 20 mg twice a day or bendroflumethiazide 2.5 mg (+0.57 g KCl) twice a day for 24 weeks, followed by a combination of half the initial dosage of both drugs for an additional 6 weeks
C
Comparator
Active comparator (nifedipine vs bendroflumethiazide) and placebo (for total reduction comparison)
O
Outcome
Reduction of supine and standing blood pressuressurrogate

Both nifedipine and bendroflumethiazide effectively reduce blood pressure in mild to moderate hypertension, with their combination providing additional blood pressure lowering.

Cite This Study

Hallin et al. (1983) studied this question.

synapsesocial.com/papers/6a758aa2ef3d015f2ddd76d9https://doi.org/10.1097/00005344-198311000-00025
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Effects of Bendroflumethiazide Added to Nifedipine in Patients With Hypertension1987 · 10 citations
  2. 2A Double-Blind Study of the Blood Pressure Lowering Effect of a Thiazide Diuretic in Hypertensive Patients Already on Nifedipine and a Beta-Blocker1987 · 19 citations
  3. 3Treating Hypertension in Non‐insulin‐Dependent Diabetes: A Comparison of Atenolol, Nifedipine, and Captopril Combined with Bendrofluazide1987 · 29 citations
  4. 4Nifedipine in the treatment of hypertension: report of a double‐blind controlled trial.1982 · 64 citations
  5. 5Nifedipine in the Treatment of Essential Hypertension1985 · 10 citations