Why the study?
Does nifedipine, bendroflumethiazide, or their combination reduce blood pressure in patients with mild or moderate hypertension?
Does nifedipine, bendroflumethiazide, or their combination reduce blood pressure in patients with mild or moderate hypertension?
Both nifedipine and bendroflumethiazide effectively reduce blood pressure in mild to moderate hypertension, with their combination providing additional blood pressure lowering.
Answers are grounded in this paper and cite their sources.
Supports low-dose nifedipine-bendroflumethiazide combination for additive BP lowering in mild-moderate hypertension; extends monotherapy data with RCT confirmation of efficacy.
In a double-blind study 30 patients with mild or moderate (World Health Organization classification I or II) hypertension were treated with either nifedipine, 20 mg twice a day, or bendroflumethiazide, 2.5 mg (+0.57 g KCl) twice a day for 24 weeks. All patients were then given a combination of half the initial dosage of both drugs for an additional period of 6 weeks. Nifedipine caused a significant reduction of both supine and standing blood pressures (16/10 and 11/5 mm Hg, respectively). Bendroflumethiazide also reduced both recumbent and standing blood pressures significantly (15/10 and 11/10 mm Hg, respectively). Combined treatment with nifedipine and bendroflumethiazide caused a further reduction of both supine and standing blood pressures. The total reduction compared with placebo was 23/12 mm Hg (p less than 0.001) and 17/11 mm Hg (p less than 0.001), respectively. There was no significant correlation between antihypertensive effect and age of patient.
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Hallin et al. (1983) studied this question.
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