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December 1, 1981British Journal of Clinical PharmacologyOpen Access

Indapamide and bendrofluazide: a comparison in the management of essential hypertension.

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Why the study?

Does indapamide reduce blood pressure compared to bendrofluazide in patients with essential hypertension?

Population

20 patients with essential hypertension

Comparison

Indapamide 2.5 mg a day vs Bendrofluazide 5 mg a day

Design

RCT, randomised

Authors

RBRF BingGlenfield HospitalGRG. I. RussellWake Forest UniversityJSJD Swales

Discussion

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Implication

Either may be selected based on tolerability, cost, or availability; confirms equivalent efficacy in this RCT.

Structured PICO

Does indapamide reduce blood pressure compared to bendrofluazide in patients with essential hypertension?

P
Population
20 patients with essential hypertension
I
Intervention
Indapamide 2.5 mg a day
C
Comparator
Bendrofluazide 5 mg a day
O
Outcome
Fall in blood pressuresurrogate

Indapamide and bendrofluazide provide equivalent blood pressure reduction in patients with essential hypertension.

Cite This Study

Bing et al. (1981) studied this question.

synapsesocial.com/papers/6a77a02b6789de8d0af753fchttps://doi.org/10.1111/j.1365-2125.1981.tb01325.x

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Changes in Plasma and Extracellular Fluid Volumes in Patients with Essential Hypertension During Long-Term Treatment with Hydrochlorothiazide1970 · 108 citations
  2. 2Angiotensin-Sodium Interaction in Blood Pressure Maintenance of Renal Hypertensive and Normotensive Rats1973 · 291 citations
  3. 3Hemodynamic Alterations in Hypertensive Patients Due to Chlorothiazide1960 · 77 citations
  4. 4Plasma Renin and Angiotensin II Measurement in Hypertensive and Normal Subjects: Correlation of Basal and Stimulated States1977 · 24 citations
  5. 5Why Do Thiazide Diuretics Lower Blood Pressure in Essential Hypertension?1967 · 75 citations