Key result
In isolated rabbit lungs, perfusion under zone 1 conditions allowed for gas exchange without anatomic or physiological shunting, potentially explaining high VA/Q seen with positive end-expiratory pressure.
Population
6 rabbit lungs in situ perfused with trisaminomethane-buffered Tyrode solution containing 1% albumin, 4%…
Comparison
Perfusion under zone 1 conditions vs Perfusion under zone 2 conditions
Design
Preclinical
Authors
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May explain high VA/Q with PEEP via zone 1 perfusion; animal data leave open human relevance.
p-value: p=<0.05
Blood flowing through vessels remaining open under zone 1 conditions exchanges gas and does not occur through shunts, potentially explaining high VA/Q seen with positive end-expiratory pressure.
Lamm et al. (1995) studied Normal lungs (animal model) (n=6). Perfusion under zone 1 conditions vs. Perfusion under zone 2 conditions was evaluated on Ventilation-perfusion (VA/Q) distribution and flow (p=<0.05). In isolated rabbit lungs, perfusion under zone 1 conditions allowed for gas exchange without anatomic or physiological shunting, potentially explaining high VA/Q seen with positive end-expiratory pressure.
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