Key result
Adiponectin gene polymorphisms G-11391A and T45G were associated with an increased 3-year risk of developing hyperglycemia (OR 1.60, P=0.004 and OR 2.71, P=0.007, respectively).
Why the study?
Do adiponectin gene polymorphisms and baseline adiponectin levels predict the development of hyperglycemia in normoglycemic subjects?
Population
Approximately 4,500 French Caucasian subjects from the Epidemiologic Data on the Insulin Resistance Syndrome…
Comparison
Adiponectin gene polymorphisms and baseline… vs Non-carriers of the risk alleles
Design
Cohort
Follow-up
3 years
Authors
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May flag higher hyperglycemia risk in normoglycemic adults; hypothesis-generating and requires prospective validation before clinical use.
Cohort (n=4,500)
Do adiponectin gene polymorphisms and baseline adiponectin levels predict the development of hyperglycemia in normoglycemic subjects?
Odds Ratio: 2.71 (95% CI 1.31–5.6)
p-value: p=0.007
Adiponectin gene polymorphisms (G-11391A and T45G) and baseline adiponectin levels independently predict the onset of hyperglycemia and changes in body fat distribution over 3 years in a French Caucasian cohort.
Fumeron et al. (2004) conducted a cohort in Normoglycemia at baseline (n=4,500). Adiponectin gene polymorphisms (G-11391A and T45G) vs. GG carriers (for G-11391A) and TT carriers (for T45G) was evaluated on Development of hyperglycemia (diabetes or impaired fasting glucose) (OR 2.71, 95% CI 1.31-5.60, p=0.007). Adiponectin gene polymorphisms G-11391A and T45G were associated with an increased 3-year risk of developing hyperglycemia (OR 1.60, P=0.004 and OR 2.71, P=0.007, respectively).
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