Key result
Homozygosity for a risk haplotype at the adiponectin locus was significantly associated with higher body weight (P=0.03) and multiple components of the insulin resistance syndrome in Caucasians.
Why the study?
Is a haplotype at the adiponectin locus associated with obesity and features of the insulin resistance syndrome in Caucasians?
Population
1,027 Caucasians, comprising an initial group of 413 nondiabetic individuals and an independent replication…
Comparison
Haplotype defined by two single nucleotide… vs Individuals without the risk haplotype
Design
Cross-sectional
Authors
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No immediate clinical change from this association; leaves open causal role of adiponectin haplotype pending prospective validation.
Observational (n=1,027)
Is a haplotype at the adiponectin locus associated with obesity and features of the insulin resistance syndrome in Caucasians?
A specific haplotype at the adiponectin locus is associated with obesity and multiple features of the insulin resistance syndrome in Caucasians, likely acting as a marker for an unidentified functional polymorphism.
Menzaghi et al. (2002) conducted an observational in Insulin resistance syndrome and obesity (n=1,027). Adiponectin locus risk haplotype (45T-->G and 276G-->T) vs. Non-homozygotes / non-risk haplotype was evaluated on Components of the insulin resistance syndrome (body weight, waist circumference, blood pressure, fasting glucose, insulin, HOMA, and lipid ratios). Homozygosity for a risk haplotype at the adiponectin locus was significantly associated with higher body weight (P=0.03) and multiple components of the insulin resistance syndrome in Caucasians.
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