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January 1, 1989Pacing and Clinical Electrophysiology

Usefulness of Rate Responsive Atrial Pacing in Patients with Sick Sinus Syndrome

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Key result

Rate responsive AAI pacing improved chronotropic response (P<0.01) and reduced blood lactate levels (P<0.05) during exercise compared to fixed rate pacing in patients with sick sinus syndrome.

Why the study?

Does rate responsive atrial pacing improve chronotropic response and blood lactate levels during exercise in patients with sick sinus syndrome?

Population

10 patients with sick sinus syndrome and normal atrioventricular conduction with an implanted activity…

Comparison

Rate responsive AAI pacing during treadmill… vs Fixed rate AAI pacing during treadmill exercise…

Design

Other

Authors

KHKiyoshi HatanoHokkaido University of EducationRKRinya KatoSaitama Medical UniversityHHHiroshi HayashiNational Institutes of Natural Sciences

Discussion

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Member takes

Overview

May support rate-responsive AAI pacing for exercise tolerance in SSS; hypothesis-generating pending randomized confirmation.

Structured PICO

Does rate responsive atrial pacing improve chronotropic response and blood lactate levels during exercise in patients with sick sinus syndrome?

P
Population
10 patients with sick sinus syndrome and normal AV conduction, plus 8 healthy volunteers, underwent treadmill exercise testing to evaluate rate responsive atrial pacing.
I
Intervention
Rate responsive AAI pacing (RR-on: rate response 10, activity threshold medium, basic rate 60 ppm, and maximum rate 150 ppm) during treadmill exercise testing.
C
Comparator
Fixed rate AAI pacing (RR-off: fixed rate 60 pulses per minute) during treadmill exercise testing.
O
Outcome
Chronotropic response and blood lactate changes during treadmill exercise testing.surrogate

Main Result

p-value: p=<0.01

Rate responsive AAI pacing improves chronotropic response and reduces lactate production during exercise in patients with sick sinus syndrome and normal AV conduction.

Cite This Study

Hatano et al. (1989) studied Sick sinus syndrome (n=18). Rate responsive AAI pacing (RR-on) vs. Fixed rate AAI pacing (RR-off, 60 ppm) and healthy volunteers was evaluated on Chronotropic response and blood lactate changes during exercise (p=<0.01). Rate responsive AAI pacing improved chronotropic response (P<0.01) and reduced blood lactate levels (P<0.05) during exercise compared to fixed rate pacing in patients with sick sinus syndrome.

synapsesocial.com/papers/6a9e6ff4ea032eb126da2d1bhttps://doi.org/10.1111/pace.1989.12.p1.16
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Activity‐Sensing, Rate‐Responsive Pacing: Improvement in Myocardial Performance with Exercise1985 · 147 citations
  2. 2Sustained improvement in exercise tolerance following physiological cardiac pacing1983 · 27 citations
  3. 3Hemodynamic and Symptomatic Consequences of Ventricular Pacing*1982 · 78 citations
  4. 4Central Venous Oxygen Saturation for the Control of Automatic Rate‐Responsive Pacing*1982 · 90 citations
  5. 5A Theoretical Right Atrial Pressure Feedback Heart Rate Control System to Restore Physiologic Control to the Rate‐limited Heart1984 · 26 citations