July 1, 1963CirculationOpen Access

Epinephrine in the Treatment of Cardiac Failure due to Shunts

View Full Paper

Ask AI

Bookmark

Why the study?

Does epinephrine infusion improve severe cardiac failure due to systemic-pulmonary shunts in infants and animal models?

Population

Closed-chest, spontaneously breathing dogs with controlled aorto-pulmonary shunts, and 3 infants with large…

Design

Preclinical

Authors

ARAbraham M. RudolphBoston University EMEmmanuel MeselAlbert Einstein College of Medicine JLJay M. LevyRetina Specialists

Discussion

Member takes

Implication

May support epinephrine as rescue in shunt-related failure; leaves open need for controlled infant trials.

Structured PICO

Does epinephrine infusion improve severe cardiac failure due to systemic-pulmonary shunts in infants and animal models?

Population

Closed-chest, spontaneously breathing dogs with controlled aorto-pulmonary shunts, and 3 infants with large left-to-right shunts and severe cardiac failure with pulmonary edema unresponsive to intensive decongestive measures.

Intervention

Epinephrine hydrochloride constant infusion (optimal rate 0.5 to 1.5 µg/Kg/min)

Outcome

Prevention or reversal of acute left ventricular failure and clinical improvement

Epinephrine infusion may be an effective rescue therapy for severe acute left ventricular failure due to systemic-pulmonary shunts in infants.

Cite This Study

Rudolph et al. (1963) studied this question.

synapsesocial.com/papers/6a9e70c79b96c7cdcc944715 https://doi.org/10.1161/01.cir.28.1.3

Topics

Heart failure HFrEF treatment Congenital heart disease adults

View Full Paper

Ask AI

Bookmark

Epinephrine in the Treatment of Cardiac Failure due to Shunts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Epinephrine in the Treatment of Cardiac Failure due to Shunts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider