Key result
Isoproterenol and dobutamine boost heart rate and blood flows without altering left-to-right shunt flow.
Why the study?
The comparative circulatory effects of isoproterenol, dopamine, and dobutamine in lambs with and without aortopulmonary left-to-right shunts were not well characterized.
What are the comparative circulatory effects of isoproterenol, dopamine, and dobutamine in conscious lambs with and without aortopulmonary left-to-right shunts?
Population
Chronically instrumented lambs with and without aortopulmonary left-to-right shunts aged 8 to 97 days
Comparison
Infusion of isoproterenol vs dobutamine vs dopamine
Design
Preclinical experimental study
Follow-up
During infusion
Authors
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These lamb findings should not guide inotrope use in shunt lesions; leaves open translation of hemodynamic effects to human neonates.
What are the comparative circulatory effects of isoproterenol, dopamine, and dobutamine in conscious lambs with and without aortopulmonary left-to-right shunts?
In a lamb model, isoproterenol and dobutamine increased systemic blood flow without increasing left-to-right shunt flow, suggesting potential utility in managing systemic perfusion in the presence of aortopulmonary shunts.
Toorop et al. (1987) studied Aortopulmonary left-to-right shunts. Isoproterenol, dopamine, and dobutamine was evaluated on Hemodynamic changes (heart rate, systemic and pulmonary blood flows, stroke volume, left-to-right shunt flow). Infusion of isoproterenol and dobutamine markedly increased heart rate and systemic and pulmonary blood flows without changing stroke volume or left-to-right shunt flow in lambs.
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