Key result
Metoprolol therapy failed to lower blood pressure (147/90 vs 151/88 mm Hg), eliminated the normal nighttime dip, and caused clinically significant BP increases in 58% of hypertensive black males.
Why the study?
Does metoprolol improve 24-h ambulatory blood pressure and preserve the nighttime blood pressure dip in hypertensive black males?
Does metoprolol improve 24-h ambulatory blood pressure and preserve the nighttime blood pressure dip in hypertensive black males?
Metoprolol failed to lower 24-hour ambulatory blood pressure in hypertensive black males and detrimentally eliminated the normal protective nighttime blood pressure dip.
Metoprolol should not be assumed effective for 24-h BP control or nocturnal dipping in hypertensive black males; leaves open race-specific therapy trials.
Twelve hypertensive black males completed the study, which was conducted to evaluate the effect of metoprolol on 24-h ambulatory blood pressure (ABP). Study participants took 50 mg to 100 mg metoprolol twice daily for a minimum of 3 weeks. Metoprolol had no significant effect on blood pressure (147/90 +/- 11/8 mm Hg v 151/88 +/- 16/8 mm Hg, baseline v treated, respectively) in spite of causing significant reductions in heart rate (87 +/- 9 beats/min v 69 +/- 7 beats/min, P < .001). Only one subject had a > or = 10 mm Hg decrease in 24-h diastolic blood pressure. The nighttime fall in blood pressure was minimized by metoprolol and clinically significant increases in daytime or nighttime blood pressure were noted in 58% of patients. Metoprolol therapy failed to lower blood pressure and eliminated the normal nighttime decline in blood pressure. Since the nighttime decline in blood pressure is thought to protect against target organ damage, it may be important to identify antihypertensive agents which preserve or enhance the nighttime blood pressure dip.
No takes yet. Share an insight, caveat, or question.
JOHNSON et al. (1995) studied Hypertension (n=12). Metoprolol vs. Baseline was evaluated on 24-h ambulatory blood pressure. Metoprolol therapy failed to lower blood pressure (147/90 vs 151/88 mm Hg), eliminated the normal nighttime dip, and caused clinically significant BP increases in 58% of hypertensive black males.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: