Why the study?
Does methyldopa administered once at bedtime maintain blood pressure control compared to three times daily dosing in patients previously well controlled on methyldopa?
Population
n=14 patients previously well controlled on methyldopa
Comparison
Methyldopa administered once at bedtime for 12… vs Methyldopa administered three times daily at the…
Design
RCT, Crossover design (either TID then HS, or reverse order), double-blind
Follow-up
24 weeks total (12 weeks per treatment period)
Authors
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Bedtime methyldopa maintains control with adherence advantages; supports simplified regimens in stable hypertension.
Does methyldopa administered once at bedtime maintain blood pressure control compared to three times daily dosing in patients previously well controlled on methyldopa?
A single bedtime dose of methyldopa provides comparable blood pressure control to a three times daily regimen, potentially improving patient adherence.
Wright et al. (1976) studied this question.
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