Key result
Sertraline hydrochloride significantly reversed depression-like behaviors and protected against myocardial injury in rats subjected to chronic unpredictable mild stress.
p-value: p=<0.05
Sertraline reverses depression-like behavior and protects against myocardial injury in a rat model of chronic unpredictable mild stress, highlighting a neuroendocrine link between depression and cardiovascular disease.
Hypothesis-generating for sertraline in comorbid depression and cardiac injury; requires human trials before any practice consideration.
Depression is generally a recurrent psychiatric disorder. Evidence shows that depression and cardiovascular diseases are common comorbid conditions, but the specific pathological mechanisms remain unclear. The purpose of this study is to determine the effects of depression induced by chronic unpredictable mild stress (CUMS) on myocardial injury and to further elucidate the biological mechanism of depression. Rats were used as a model. The CUMS procedure lasted for a total of 8 weeks. After 4 weeks of CUMS, treated rats exhibited a reduced sucrose preference and changes in scores on an open field test, body weight and content of 5-HT in the brain as compared with the values of these variables in controls. These changes indicated depression-like changes in CUMS rats and demonstrated the feasibility of the depression model. In addition, pathological changes in the myocardium and increased cardiomyocyte apoptosis demonstrated that myocardial injury had occurred after 6 weeks of CUMS and had increased significantly by the end of 8 weeks of CUMS. Plasma serotonin (5-HT), norepinephrine (NE) and epinephrine (E), all depression-related neuroendocrine factors, were measured by HPLC-ECD techniques, and the content of plasma corticosterone (GC) was evaluated by an I(125)-cortisol radioactivity immunoassay in control and CUMS rats. The results indicated that 5-HT had decreased, whereas NE, E and GC had increased in CUMS rats, and these factors might be associated with depression-induced myocardial injury. The effects of 5-HT, NE and GC on the survival rate of cultured cardiomyocytes were determined using an orthogonal design. The results showed that 5-HT was a more important factor affecting cell survival than GC or NE. The results suggested that normal blood levels of 5-HT had a cytoprotective effect. The neuroendocrine disorders characterized by decreased 5-HT combined with increased GC and NE mediated the occurrence of depression-induced myocardial injury.
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Xinxing et al. (2014) studied Depression-like behavior and myocardial injury (n=32). Sertraline hydrochloride vs. CUMS without sertraline was evaluated on Open field test score, sucrose preference, and myocardial injury (p=<0.05). Sertraline hydrochloride significantly reversed depression-like behaviors and protected against myocardial injury in rats subjected to chronic unpredictable mild stress.
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