Key result
Enflurane and isoflurane uptake rates between 10 and 60 minutes were similar or higher during spontaneous versus controlled ventilation.
Why the study?
Does spontaneous versus controlled ventilation affect the uptake rates of enflurane and isoflurane during anesthesia?
Observational (n=40)
Does spontaneous versus controlled ventilation affect the uptake rates of enflurane and isoflurane during anesthesia?
During anesthesia, the uptake rates of enflurane and isoflurane are similar or higher during spontaneous ventilation compared to controlled ventilation despite lower minute ventilation volumes.
Answers are grounded in this paper and cite their sources.
Uptake rates may remain similar or higher with spontaneous ventilation; leaves open ventilation-mode effects on volatile kinetics.
The uptake of enflurane and of isoflurane were studied in forty patients during anaesthesia with nitrous oxide using either spontaneous or controlled ventilation. A Douglas bag method was used in combination with low fresh gas flows to a circle system and constant end-tidal anaesthetic concentration. The mean enflurane uptake rates were between 24 and 14 ml.70kg-1.min-1 between 10 and 60 minutes. Corresponding isoflurane uptake rates were between 15 and 8 ml. 70 kg-1.min-1. The initial uptake rates were lower than expected from "the square root of time concept". During spontaneous ventilation, the anaesthetic uptake rates were similar or even higher than corresponding rates during controlled ventilation in spite of lower minute ventilation volumes.
No takes yet. Share an insight, caveat, or question.
Bengtson et al. (1992) conducted an observational in Anaesthesia (n=40). Spontaneous ventilation vs. Controlled ventilation was evaluated on Anaesthetic uptake rates. Enflurane and isoflurane uptake rates between 10 and 60 minutes were similar or higher during spontaneous versus controlled ventilation.
Synapse has enriched 10 related papers. Consider them for comparative context: