Key result
Clamping sympathetic activity resulted in significantly lower laser-Doppler flowmetry responses to direct and indirect heat stress compared to sham-operated controls, but did not affect capillary blood cell velocity.
Why the study?
Does clamping sympathetic activity alter cutaneous blood flow responses to heat stress in rats?
Population
Anesthetized rats (with additional studies on unanesthetized animals)
Comparison
Clamping sympathetic activity to the tail to… vs Sham-operated control rats
Design
Preclinical
Authors
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Should not yet inform human heat stress management; hypothesis-generating for differential sympathetic control of cutaneous AVAs versus arterioles.
Does clamping sympathetic activity alter cutaneous blood flow responses to heat stress in rats?
Withdrawal of sympathetic constrictor tone plays a role in the response of cutaneous arteriovenous anastomoses, but not precapillary arterioles, to direct and indirect heat stress.
Richardson et al. (1991) studied this question. Clamping sympathetic activity (SC) vs. Sham-operated control rats was evaluated on Blood flow responses in cutaneous arteriovenous anastomoses (AVAs) and capillaries. Clamping sympathetic activity resulted in significantly lower laser-Doppler flowmetry responses to direct and indirect heat stress compared to sham-operated controls, but did not affect capillary blood cell velocity.
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