What is the clinical evidence from this study?

Study design: Other. Intervention: Clamping sympathetic activity (SC) vs. Sham-operated control rats. Primary outcome: Blood flow responses in cutaneous arteriovenous anastomoses (AVAs) and capillaries.

What does this research mean for the field?

Withdrawal of sympathetic constrictor tone mediates cutaneous arteriovenous anastomosis blood flow responses to direct and indirect heat stress, while capillary blood flow is unaffected. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 1, 1991Journal of Applied Physiology

Activity of pulmonary surfactant after blocking the associated proteins SP-A and SP-B

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Key result

Clamping sympathetic activity in rats reduces AVA blood flow responses to heat stress, sparing capillaries.

Why the study?

The role of sympathetic withdrawal on blood flow responses in cutaneous arteriovenous anastomoses and capillaries during direct and indirect heat stress was unclear.

Does clamping sympathetic activity alter blood flow responses in cutaneous arteriovenous anastomoses and capillaries to heat stress in rats?

Population

Anesthetized rats with additional studies in unanesthetized rats

Comparison

Clamping sympathetic activity to the tail vs sham-operated control rats

Design

Preclinical experimental study

Authors

TKTsutomu KobayashiOhkawara Neurosurgical Hospital KNKeiko NittaHawaii Department of Health RTRyuhei Takahashi

Discussion

Member takes

Implication

Sympathetic drive appears necessary for AVA dilation during heat stress in rats; leaves open whether this mechanism translates to human thermoregulation.

Structured PICO

Does clamping sympathetic activity alter blood flow responses in cutaneous arteriovenous anastomoses and capillaries to heat stress in rats?

Population

Anesthetized and unanesthetized rats subjected to direct and indirect heat stress.

Intervention

Clamping sympathetic activity (SC) to the tail during exposure to direct (tail) or indirect (body) heating to 35 degrees C

Comparator

Sham-operated control rats

Outcome

Blood flow responses in cutaneous arteriovenous anastomoses (AVAs) evaluated by laser-Doppler flowmetry (LDF) and capillary flow evaluated by videodensitometry measurements of blood cell velocity (CBV)surrogate

Withdrawal of sympathetic constrictor tone plays a role in the response of cutaneous arteriovenous anastomoses, but not precapillary arterioles, to direct and indirect heat stress.

Cite This Study

Kobayashi et al. (1991) studied this question. Clamping sympathetic activity (SC) vs. Sham-operated control rats was evaluated on Blood flow responses in cutaneous arteriovenous anastomoses (AVAs) and capillaries. Clamping sympathetic activity in rats resulted in significantly lower AVA blood flow responses to heat stress compared to sham controls, while capillary blood flow was unaffected.

synapsesocial.com/papers/6aae0dc384a76b509095ab50 https://doi.org/10.1152/jappl.1991.71.2.530

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Implication

Sympathetic drive appears necessary for AVA dilation during heat stress in rats; leaves open whether this mechanism translates to human thermoregulation.

Activity of pulmonary surfactant after blocking the associated proteins SP-A and SP-B

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Activity of pulmonary surfactant after blocking the associated proteins SP-A and SP-B

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider