Key result
Tolmesoxide lowered blood pressure in hypertensive rats and cats through a direct relaxant effect on vascular smooth muscle, accompanied by tachycardia.
Why the study?
Does tolmesoxide reduce blood pressure in hypertensive animal models?
Does tolmesoxide reduce blood pressure in hypertensive animal models?
Tolmesoxide lowers blood pressure in animal models through a direct relaxant effect on vascular smooth muscle.
Should not change clinical practice; leaves open tolmesoxide's antihypertensive potential pending human trials.
1 The blood pressure of conscious, deoxycorticosterone acetate (DOCA) hypertensive and 1 kidney Goldblatt hypertensive rats and renal hypertensive and normotensive cats was reduced by tolmesoxide (4,5-dimethoxy-o-tolyl methyl sulphoxide). 2 Tachycardia accompanied the hypotension. In rats the increase in heart rate was abolished by concurrent administration of propranolol. Tachycardia did not occur in pithed rats. 3 Vascoconstriction induced by sympathetic stimulation, noradrenaline, tyramine, angiotensin or vasporessin was antagonized by tolmesoxide. 4 The antagonism of vasoconstrictor responses produced by tolmesoxide was unaffected by beta-adrenoceptor, muscarinic or histamine antagonists. 5 It is concluded that the lowering of pressure produced by tolmesoxide results from a defect relaxant effect on vascular smooth muscle.
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John C. Doxey (1978) studied Hypertension. Tolmesoxide was evaluated on Blood pressure reduction. Tolmesoxide lowered blood pressure in hypertensive rats and cats through a direct relaxant effect on vascular smooth muscle, accompanied by tachycardia.
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