Key result
In Japanese patients with type 2 diabetes, non-HDLC (HR 1.78; 95% CI 1.43-2.21) was the best predictor of incident CHD in men, whereas triglycerides were most predictive in women.
Why the study?
Which lipid variable best predicts incident coronary heart disease in Japanese men and women with type 2 diabetes?
Population
1,771 Japanese men and women aged 40-70 years with type 2 diabetes from 59 institutes nationwide.
Design
Cohort
Follow-up
planned 8-year period
Authors
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May support sex-specific lipid monitoring in Japanese T2D; leaves open validation and therapeutic trials.
Cohort (n=1,771)
Yes
Which lipid variable best predicts incident coronary heart disease in Japanese men and women with type 2 diabetes?
Hazard Ratio: 1.78 (95% CI 1.43–2.21)
Non-HDL cholesterol and TC/HDL-C ratio are the best predictors of incident CHD in Japanese men with type 2 diabetes, while triglycerides are the best predictor in women, highlighting prominent sex differences in risk assessment.
Sone et al. (2012) conducted a cohort in Type 2 diabetes (n=1,771). Lipid variables (non-HDLC, TC/HDLC, TGs) vs. Lower levels (per 1 SD increment or bottom tertile) was evaluated on Incident coronary heart disease (CHD) (HR 1.78, 95% CI 1.43-2.21). In Japanese patients with type 2 diabetes, non-HDLC (HR 1.78; 95% CI 1.43-2.21) was the best predictor of incident CHD in men, whereas triglycerides were most predictive in women.