Key result
Age was associated with an increase in maximum wall stress following norepinephrine and potassium, and a decrease in cell water, Mg, and K contents in arterial smooth muscle of developing dogs.
In developing dogs, aging is associated with increased arterial smooth muscle maximum wall stress and changes in electrolyte composition, suggesting alterations in excitation-contraction coupling.
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Hypothesis-generating for age effects on arterial smooth muscle in dogs; leaves open translation to human vascular aging or hypertension.
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Cox et al. (1976) studied Normal growth and development. Age (growth and development) vs. Different ages (puppies vs mothers) was evaluated on Arterial smooth muscle mechanics and electrolyte composition. Age was associated with an increase in maximum wall stress following norepinephrine and potassium, and a decrease in cell water, Mg, and K contents in arterial smooth muscle of developing dogs.
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