Key result
Venous, arterial, and tail bleeding models are similarly affected by impaired coagulation, while platelet function defects have a greater influence in models incorporating arterial injury.
Population
Mice (murine bleeding models including saphenous vein, artery, and tail tip transection)
Design
Preclinical
Authors
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Urges caution selecting murine bleeding models for antithrombotic testing; leaves open standardization for clinical translation.
In murine models, venous, arterial, and tail bleeding are similarly affected by impaired coagulation, whereas platelet function defects predominantly influence models with arterial injury.
Vaezzadeh et al. (2014) studied Haemostatic impairments. Unfractionated heparin (UFH) or αIIbβ3 inhibitory antibody (Leo.H4) was evaluated on Sensitivity of bleeding models (EC50 dose). Venous, arterial, and tail bleeding models are similarly affected by impaired coagulation, while platelet function defects have a greater influence in models incorporating arterial injury.
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