Key result
Wistar Furth rats were protected from chronic renal disease progression after renal mass reduction compared to Sprague Dawley rats, associated with maintained nitric oxide production.
Elevated nitric oxide production in Wistar Furth rats protects against the progression of chronic renal disease following renal mass reduction.
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Animal data on nitric oxide in renal ablation models should not guide practice; leaves open relevance to human CKD progression.
Erdely et al. (2003) studied Chronic renal disease. Wistar Furth (WF) strain vs. Sprague Dawley (SD) strain was evaluated on Progression of chronic renal disease (proteinuria, kidney damage, renal function). Wistar Furth rats were protected from chronic renal disease progression after renal mass reduction compared to Sprague Dawley rats, associated with maintained nitric oxide production.
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