Key result
Wistar-Furth rats do not develop proteinuria or significant renal injury after chronic nitric oxide synthase inhibition at doses that cause significant injury in Sprague Dawley rats.
Why the study?
Does chronic nitric oxide synthase inhibition cause renal injury in Wistar-Furth rats compared to Sprague Dawley rats?
Does chronic nitric oxide synthase inhibition cause renal injury in Wistar-Furth rats compared to Sprague Dawley rats?
Wistar-Furth rats are resistant to renal injury from chronic nitric oxide synthase inhibition, a protection that may be mediated by resistance to glomerular hypertension.
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Rat strain differences in NOS inhibition renal injury caution against model generalization to humans; leaves open genetic modifiers of CKD susceptibility.
Erdely et al. (2005) studied Chronic kidney disease. N(G)-nitro-l-arginine methyl ester (l-NAME) vs. Sprague Dawley rats was evaluated on Proteinuria and renal injury. Wistar-Furth rats do not develop proteinuria or significant renal injury after chronic nitric oxide synthase inhibition at doses that cause significant injury in Sprague Dawley rats.
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