Population
Sprague-Dawley rats (240-260 g) obtained from either Harlan or Charles River Laboratories
Comparison
Nomega-nitro-L-arginine methyl ester in drinking… vs Comparison between rats from Harlan vs. Charles…
Design
Preclinical
Follow-up
2 weeks
Authors
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Supplier differences alter L-NAME hypertensive responses in rats; leaves open whether this variability confounds preclinical cardiovascular studies.
Sprague-Dawley rats from different suppliers exhibit significantly different baseline blood pressures and hypertensive responses to chronic NO synthase inhibition, which may confound preclinical study results.
Pollock et al. (1998) studied this question.
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