Key result
Familial hyperlipidemia was identified in 60% of hyperlipidemic young patients with non-embolic ischemic stroke, compared to 0% of normolipidemic patients.
Observational (n=25)
Screening family members of young patients with non-embolic ischemic stroke and hyperlipidemia may identify high-risk individuals for primary prevention.
Serum cholesterol, low density lipoproteins (LDL), very low density lipoproteins (VLDL) and chylomicron levels were studied in 25 young patients (age 40 years or less) of non-embolic ischemic stroke of unknown aetiology. Fifteen patients were males and 10 were females. The prevalence of hyperlipidemia was found to be 60%. Frederickson's type IIb hyperlipoproteinemia was the commonest (32%) abnormal pattern observed, followed by type IIa (12%), type IV (12%) and type V (4%). Family studies were carried out in all the 25 index patients (15 hyperlipidemic and 10 normolipidemic). Familial hyperlipidemia (i.e. 2 or more hyperlipidemic members in the same family) was found in 9 of the 15 hyperlipidemic index patients and in none of the normolipidemic index patients. The common pattern was found to be that of familial combined hyperlipidemia. The study indicates that screening the family members of hyperlipidemic young patients of non-embolic ischemic stroke may delineate a group of high risk individuals for possible primary prevention before they develop the disease.
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Bansal et al. (1986) conducted an observational in Non-embolic ischemic stroke of unknown aetiology (n=25). Hyperlipidemia vs. Normolipidemia was evaluated on Familial hyperlipidemia (2 or more hyperlipidemic members in the same family). Familial hyperlipidemia was identified in 60% of hyperlipidemic young patients with non-embolic ischemic stroke, compared to 0% of normolipidemic patients.
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