Key result
Phosphoramidon, an inhibitor of neutral endopeptidase 24,11, almost completely suppressed the production of three of the four major fragments of endothelin 1 hydrolysis by rat kidney membranes.
Endothelin 1 is metabolized in rat kidney membranes by both endopeptidase 24,11 and a phosphoramidon-insensitive metallo-endopeptidase, with distinct cleavage sites and efficiencies.
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Identifies dual endothelin-1 hydrolysis pathways in rat kidney; leaves open their roles in human disease and therapeutic targeting.
Yamaguchi et al. (1992) studied this question. Phosphoramidon was evaluated on Hydrolysis of endothelin 1. Phosphoramidon, an inhibitor of neutral endopeptidase 24,11, almost completely suppressed the production of three of the four major fragments of endothelin 1 hydrolysis by rat kidney membranes.
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