Key result
Urinary activity of lysosomal and ET-1 peptidase was significantly increased in patients with hypertension and children with chronic renal failure compared with controls (P < 0.001).
Observational
p-value: p=< 0.001
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No immediate clinical implications for hypertension or CKD management; leaves open whether these peptidases are biomarkers or targets.
Janas et al. (2000) conducted an observational in Hypertension, chronic renal failure. Hypertension and chronic renal failure vs. Healthy subjects or children with stable renal allograft was evaluated on Activity of lysosomal and ET-1 peptidase in the urine (p=< 0.001). Urinary activity of lysosomal and ET-1 peptidase was significantly increased in patients with hypertension and children with chronic renal failure compared with controls (P < 0.001).
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