This is the first reported case of successful coronary artery bypass grafting in a patient with Glanzmann's thrombasthenia.
Supports feasibility of CABG in Glanzmann's thrombasthenia; first case leaves open need for standardized protocols.
Glanzmann's thrombasthenia is a platelet aggregation disorder resulting from a functional loss of platelet membrane glycoprotein IIb-IIIa. First described by Dr. Glanzmann in 1918, the disorder is characterized clinically by mucocutaneous bleeding and physiologically by absent platelet aggregation to collagen, epinephrine, and adenosine diphosphate stimulation. While there are multiple reports of patients with Glanzmann's thrombasthenia undergoing surgery, to our knowledge there has been no report of a patient with Glanzmann's undergoing coronary artery bypass grafting. We present the first such report of a patient who successfully underwent operative coronary artery revascularization, and offer suggestions for future management of these patients.
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Ryckman et al. (2005) studied this question.
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