Key result
One-anastomosis gastric bypass significantly reduced mean body weight from 116.75 kg to 69.66 kg at 24 months (p<0.001), alongside significant improvements in lipid profile.
Why the study?
Morbid obesity directly impacts cardiovascular disease development, and one-anastomosis gastric bypass is used to control body weight and reduce cardiovascular risk.
Does one-anastomosis gastric bypass improve lipid profile, body weight, and cardiovascular risk in obese patients?
Observational (n=100)
Does one-anastomosis gastric bypass improve lipid profile, body weight, and cardiovascular risk in obese patients?
Absolute Event Rate: 69.66% vs 116.75%
p-value: p=<0.001
One-anastomosis gastric bypass significantly reduces body weight and improves lipid profiles and cardiovascular risk markers at 24 months in obese patients.
OAGB was associated with weight loss and CV risk marker improvement at 24 months; hypothesis-generating and requires controlled trials before practice change.
Morbid obesity has a direct impact on the development of cardiovascular disease. One-anastomosis gastric bypass (OAGB) is an effective surgical technique for the control of body weight and the reduction of cardiovascular risk. This work examines the change in weight loss, lipid profile and cardiovascular risk in 100 patients (71 women, 29 men), mean age 42.61 ± 11.33 years at 3, 6, 9, 12, 18 and 24 months after OAGB. At 24 months post-surgery, mean body weight was significantly reduced compared to pre-operative values (116.75 ± 22.19 kg vs. 69.66 ± 13.07 kg), as were mean total cholesterol (201.86 ± 44.60 mg/dL vs. 172.99 ± 32.26 mg/dL), LDL (Low-Density Lipoprotein) cholesterol (126.90 ± 39.81 mg/dL vs. 96.28 ± 26.99 mg/dL), triglycerides (138.05 ± 78.45 mg/dL vs. 76.04 ± 30.34 mg/dL) and cardiovascular risk (total cholesterol/HDL (High-Density Lipoprotein) cholesterol: 4.32 ± 1.24 vs. 2.93 ± 0.71), while the mean HDL cholesterol concentration was significantly higher (49.09 ± 14.16 mg/dL vs. 61.98 ± 14.86 mg/dL) (all p < 0.001). In conclusion, OAGB surgery led to significant reductions in body weight, a significant improvement in the lipid profile, and a reduction in cardiovascular risk.
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Jiménez et al. (2020) conducted an observational in Morbid obesity (n=100). One-anastomosis gastric bypass (OAGB) vs. Pre-operative values was evaluated on Body weight (p=<0.001). One-anastomosis gastric bypass significantly reduced mean body weight from 116.75 kg to 69.66 kg at 24 months (p<0.001), alongside significant improvements in lipid profile.
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