Key result
Oral antiarrhythmic drugs caused a mean decrease in the atrial paced heart rate producing AV Wenckebach phenomenon of 19.2 beats/min (P<0.01), indicating deterioration of anterograde AV conduction.
Why the study?
Do oral antiarrhythmic drugs decrease the atrial paced heart rate producing AV Wenckebach phenomenon in patients with symptomatic sinus node dysfunction after atrial pacemaker implantation?
Population
24 patients with symptomatic sinus node dysfunction and intact anterograde AV conduction who underwent…
Comparison
Oral antiarrhythmic drugs vs No antiarrhythmic drugs
Design
Cohort
Follow-up
Up to 3 years
Authors
Loading...
May warrant caution with antiarrhythmic drugs in paced sinus node dysfunction; supports drug effect over progression but remains hypothesis-generating.
Cohort (n=24)
Do oral antiarrhythmic drugs decrease the atrial paced heart rate producing AV Wenckebach phenomenon in patients with symptomatic sinus node dysfunction after atrial pacemaker implantation?
Effect estimate: mean decrease of 19.2 beats/min
p-value: p=<0.01
Deterioration of anterograde AV conduction in patients with sinus node dysfunction after atrial pacemaker implantation is primarily driven by antiarrhythmic drug therapy rather than intrinsic disease progression.
Mechelen et al. (1984) conducted a cohort in Symptomatic sinus node dysfunction (n=24). Antiarrhythmic drugs vs. No antiarrhythmic drugs was evaluated on Change in atrial paced heart rate producing AV Wenckebach phenomenon (AVWHR) (mean decrease of 19.2 beats/min, p=<0.01). Oral antiarrhythmic drugs caused a mean decrease in the atrial paced heart rate producing AV Wenckebach phenomenon of 19.2 beats/min (P<0.01), indicating deterioration of anterograde AV conduction.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: