Key result
A free vein graft between the aorta and coronary sinus followed by partial sinus occlusion resulted in intimal hyperplasia of the coronary sinus, vein dilatation, and no vein occlusion.
Why the study?
Does retrograde perfusion via a vein graft to the coronary sinus preserve myocardial vascular channels after coronary artery occlusion?
Does retrograde perfusion via a vein graft to the coronary sinus preserve myocardial vascular channels after coronary artery occlusion?
Early experimental evidence demonstrating the feasibility of retrograde myocardial perfusion via the coronary venous system.
Caution against clinical use of coronary sinus grafting; leaves open feasibility of retrograde perfusion in experimental ischemia models.
A free graft of vein was placed between the aorta and coronary sinus. Three weeks later the sinus was partially occluded at its ostium in the right auricle. Blood from the aorta was made available to the myocardium by way of the venous system. After these procedures were done a histologic study of the venous and arterial channels was carried out. The coronary sinus and its tributaries showed hyperplasia of the intima. The anterior cardiac veins showed dilatation with little or no hyperplasia of intima. None of the veins became occluded. Complete occlusion of major coronary arteries was done. These arteries distal to the occlusion showed medial sclerosis and atrophy. They did not show thrombosis. The myocardium distal to an occluded artery showed many vascular channels.
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Hahn et al. (1952) studied Myocardial revascularization. Free vein graft between aorta and coronary sinus with partial occlusion of sinus ostium was evaluated on Histologic changes in venous and arterial channels. A free vein graft between the aorta and coronary sinus followed by partial sinus occlusion resulted in intimal hyperplasia of the coronary sinus, vein dilatation, and no vein occlusion.
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