Key result
Non-alcoholic steatohepatitis (NASH) is associated with a higher risk of cardiovascular disease and mortality than simple steatosis.
Highlights the link between non-alcoholic fatty liver disease (NAFLD/NASH) and cardiovascular disease, specifically heart valve disease.
Non-alcoholic fatty liver disease (NAFLD ) occurs when fatty infiltration affects more than 5% of liver tissue, in the presence of less than 20 g (2.5 U) of alcohol consumption per day, after ruling out other causes of liver affections. NAFLD is a slowly progressive condition including a wide range of liver diseases with varying degrees of severity (from simple steatosis to coexistent inflammation with hepatocyte necrosis and fibrosis, to cirrhosis). Non-alcoholic steatohepatitis (NASH) is a more advanced stage of NAFLD disease, i.e. it occurs when an inflammatory component appears in addition to steatosis, resulting in a higher risk of cardiovascular (CV) disease and mortality than steatosis only.
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Pingitore et al. (2020) conducted a review in Non-alcoholic fatty liver disease (NAFLD) and heart valve disease. Non-alcoholic fatty liver disease (NAFLD) vs. Simple steatosis was evaluated. Non-alcoholic steatohepatitis (NASH) is associated with a higher risk of cardiovascular disease and mortality than simple steatosis.
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