Key result
Coronary blood flow remained elevated at 282% of control after 20s of reflow despite high-energy phosphates returning to control levels, indicating dissociation during reactive hyperemia.
Population
12 open-chest anesthetized pigs
Comparison
24 s occlusion of the anterior descending… vs Baseline/control levels prior to occlusion
Design
Preclinical
Authors
Loading...
Uncoupling of coronary flow from high-energy phosphates in animal reactive hyperemia; challenges metabolic control assumptions but leaves open human relevance.
The control of coronary blood flow is not closely coupled to the levels of myocardial high-energy phosphates during reactive hyperemia.
Schwartz et al. (1990) studied Myocardial reactive hyperemia (n=12). 24 s occlusion of the anterior descending coronary artery vs. Baseline/control was evaluated on Myocardial high-energy phosphate (HEP) metabolism and coronary blood flow (CBF) during reactive hyperemia. Coronary blood flow remained elevated at 282% of control after 20s of reflow despite high-energy phosphates returning to control levels, indicating dissociation during reactive hyperemia.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: