Key result
Electrical stimulation of nerves and administration of ACh, oxytocin, glibenclamide, and bombesin induced the release of 1-20 ng of an insulin-like peptide from perfused extirpated cat legs.
Population
Extirpated cat legs perfused with Tyrode's solution
Comparison
Electrical stimulation of the sciatic or… vs Unstimulated conditions
Design
Preclinical
Authors
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Hypothesis-generating for peripheral insulin-like peptide sources; requires in vivo confirmation before any translational relevance.
Electrical stimulation and specific pharmacological agents induce the release of an insulin-like peptide from isolated cat leg preparations, suggesting a peripheral nervous or muscular pool of insulin.
POSLONCEC et al. (1985) studied this question. Electrical stimulation and administration of ACh, bombesin, oxytocin, and glibenclamide vs. Unstimulated conditions was evaluated on Insulin-like immunoreactivity (ILI) levels in perfusate. Electrical stimulation of nerves and administration of ACh, oxytocin, glibenclamide, and bombesin induced the release of 1-20 ng of an insulin-like peptide from perfused extirpated cat legs.
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